In practice, the main languages people hold up as being capable of doing this--Lisp, Smalltalk, and Forth--seem to have totally failed. I run both Windows and Linux and I can't think of a single application for either operating system that uses anyone of those three languages.
Let me say that again, so far as I can tell, neither Lisp (in any of its flavors: Common Lisp, Scheme, or Logo), nor Smalltalk, nor Forth are in production in any meaningful way at any level on any personal computer.
I kind of wish it weren't so because I love these languages, in theory, but in practice they always fall down.
That is about as damning as it gets.
Go ahead. Prove me wrong.